Hemostatic Parameters in Newborn - II. Sequential Study During the First Four Weeks of Life

J K Kolindewala; B Dube; V Bhargava; R K Dube; V L N Kota; B K Das

doi:10.1055/s-0038-1661445

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1986; 55(01): 051-053
DOI: 10.1055/s-0038-1661445

Original Article

Schattauer GmbH Stuttgart

Hemostatic Parameters in Newborn - II. Sequential Study During the First Four Weeks of Life

J K Kolindewala

Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

,

B Dube

^*Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

,

V Bhargava

Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

,

R K Dube

^*Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

,

V L N Kota

Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

,

B K Das

Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

› Author Affiliations

Abstract

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Summary

A sequential study of kaolin cephalin clotting time (KCCT), prothrombin time (PT), thrombin time (TT), plasma fibrinogen and serum FDP was conducted during the first four weeks of life on term and preterm babies. A “physiological dip” of PT and TT was noted inappropriate for gestational age (AGA) babies both term and preterm; in case of KCCT, the dip was significant in term AGA babies only. At the end of four weeks, PT and TT had moderately improved in term babies but showed little improvement in preterm ones; KCCT reached almost an adult value in all babies except in preterm AGA and term LGA (large for gestational age) ones. Plasma fibrinogen showed no “physiological dip” and reached adult level in two to four weeks. Serum FDP levels were appreciably raised in preterm AGA babies only at birth and there too normalised by 72 h.

Key words

Neonate - Preterm - Term - SGA - AGA - LGA - Blood coagulation - Hemostasis

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References

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